Pronunciation: eye-soe-SOR-bide dye-NYE-trate
Generic Name: Isosorbide Dinitrate Extended-Release
Brand Name: Dilatrate-SR
Isosorbide Dinitrate Extended-Release is used for:
Preventing symptoms of angina (chest pain) caused by heart disease. Isosorbide Dinitrate Extended-Release is used alone or with other medicines. Isosorbide Dinitrate Extended-Release is NOT intended for the immediate relief of acute attacks of angina. It may also be used for other conditions as determined by your doctor.
Isosorbide Dinitrate Extended-Release is a nitrate. It works by relaxing the blood vessels in the body, allowing them to widen. This lets more blood flow through the blood vessels, which reduces the work the heart has to do to pump blood. This reduces the oxygen needs of the heart and makes chest pain go away.
Do NOT use Isosorbide Dinitrate Extended-Release if:
- you are allergic to any ingredient in Isosorbide Dinitrate Extended-Release
- you are taking a phosphodiesterase type 5 inhibitor (eg, sildenafil), a medicine often used for sexual dysfunction
Contact your doctor or health care provider right away if any of these apply to you.
Before using Isosorbide Dinitrate Extended-Release:
Some medical conditions may interact with Isosorbide Dinitrate Extended-Release. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have bleeding in the brain, a recent head trauma, a heart attack, an overactive thyroid, or anemia (a low red blood cell count)
Some MEDICINES MAY INTERACT with Isosorbide Dinitrate Extended-Release. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Ethanol or phosphodiesterase type 5 inhibitors (eg, sildenafil) because side effects such as extremely low blood pressure, dizziness, or fainting may occur
This may not be a complete list of all interactions that may occur. Ask your health care provider if Isosorbide Dinitrate Extended-Release may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Isosorbide Dinitrate Extended-Release:
Use Isosorbide Dinitrate Extended-Release as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Isosorbide Dinitrate Extended-Release by mouth on an empty stomach with a full glass of water (8 oz/240 mL).
- Swallow Isosorbide Dinitrate Extended-Release whole. Do not break, crush, or chew before swallowing.
- If you miss a dose of Isosorbide Dinitrate Extended-Release, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Isosorbide Dinitrate Extended-Release.
Important safety information:
- Isosorbide Dinitrate Extended-Release may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Isosorbide Dinitrate Extended-Release with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Isosorbide Dinitrate Extended-Release may cause dizziness or lightheadedness; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- When you begin taking Isosorbide Dinitrate Extended-Release, it may give you a headache. This usually becomes less noticeable with time. This is a sign that the medicine is working. Do not change your dosing schedule to avoid headaches. Take aspirin or acetaminophen with Isosorbide Dinitrate Extended-Release to avoid headaches.
- Isosorbide Dinitrate Extended-Release should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Isosorbide Dinitrate Extended-Release while you are pregnant. It is not known if Isosorbide Dinitrate Extended-Release is found in breast milk. If you are or will be breast-feeding while you use Isosorbide Dinitrate Extended-Release, check with your doctor. Discuss any possible risks to your baby.
When used for long periods of time or at high doses, Isosorbide Dinitrate Extended-Release may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Isosorbide Dinitrate Extended-Release stops working well. Do not take more than prescribed. Some people who use Isosorbide Dinitrate Extended-Release for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as physical DEPENDENCE. If you stop taking Isosorbide Dinitrate Extended-Release suddenly, you may have WITHDRAWAL symptoms. These may include rapid heartbeat, chest pain, and even heart attack.
Possible side effects of Isosorbide Dinitrate Extended-Release:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dizziness; flushing of the face and neck; headache; lightheadedness; nausea; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; frequent or continuing chest pain; rapid heartbeat.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Isosorbide Dinitrate Extended-Release side effects (in more detail)
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; diarrhea; difficulty breathing; dizziness; headache; irregular and/or forceful heartbeat; loss of consciousness; nausea; seizures; slow pulse; stomach pain; sweating; vision problems; vomiting.
Proper storage of Isosorbide Dinitrate Extended-Release:
Store Isosorbide Dinitrate Extended-Release at room temperature between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Isosorbide Dinitrate Extended-Release out of the reach of children and away from pets.
General information:
- If you have any questions about Isosorbide Dinitrate Extended-Release, please talk with your doctor, pharmacist, or other health care provider.
- Isosorbide Dinitrate Extended-Release is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information is a summary only. It does not contain all information about Isosorbide Dinitrate Extended-Release. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
More Isosorbide Dinitrate Extended-Release resources
- Isosorbide Dinitrate Extended-Release Side Effects (in more detail)
- Isosorbide Dinitrate Extended-Release Use in Pregnancy & Breastfeeding
- Drug Images
- Isosorbide Dinitrate Extended-Release Drug Interactions
- Isosorbide Dinitrate Extended-Release Support Group
- 2 Reviews for Isosorbide Dinitrate Extended-Release - Add your own review/rating
Compare Isosorbide Dinitrate Extended-Release with other medications
- Angina
- Angina Pectoris Prophylaxis
- Esophageal Spasm
- Heart Failure
- Pulmonary Arterial Hypertension
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